As a social species, humans have an inherent need to feel connected to others and to feel like we belong with others. Existing medical research demonstrates that social isolation--defined as the perceived absence of feeling socially connected--during childhood and adolescence has both concurrent and longterm negative mental and physical health effects. Conversely related, education research finds that school belonging or connectedness is important for motivational, behavioral, and school performance outcomes. An organization called Beyond Differences was created to reduce social isolation and support connectedness in schools, particularly middle schools. The organization trains middle and high school students to lead social change through a collection of youth-led efforts, including assemblies, curriculum, and leadership training for middle school students, as well as larger national campaigns to raise awareness and catalyze social change.