Web 2.0 is a revolutionary technology operates Facebook, WhatsApp, LinkedIn, Twitter, and Google+ and other social networks. The study aimed to explore the effects of individual and collaborative web 2.0 technologies on the learning performance and self-regulation of secondary school students over traditional approach of learning. One hundred ten participants assigned for non-web 2.0 group (n = 40), individual web 2.0 group (n = 40) and collaborative web 2.0 (n = 30). Nonequivalent pretest post test quasi-experimental design used to conduct the experiment where samples were not randomly selected rather the whole class students were the participants of the study. Individual web 2.0 used Slideshare, Wiki, Whatsapp, and Youtube and Collaborative web 2.0 used the similar tools such as Slideshare, Wiki, Whatsapp, Youtube counted as the experimental class I and II, and conventional lecture was used in non-web 2.0 group or comparative group. Before and after instruction, self-regulatory learning test (Bhattacharjee and Jena, 2017a) and achievement test in tissue (Bhattacharjee and Jena, 2017b) used to collect the data. It resulted that collaborative and individual web 2.0 technology has significant effects on learning performance and self-regulation of learning over traditional approach of secondary school students in Silchar, India.