This study focused on primary teachers' views of co-teaching approaches in addressing the learning needs of pupils with special educational needs (SEN) in multi-grade classrooms in Irish primary schools. A case study incorporating a mixed methods approach was chosen. Views of 22 multi-grade and special education teachers (SET) were ascertained through self-administered questionnaires and semi-structured interviews. The findings indicate that while teachers believe the learning needs of pupils with SEN can be met through co-teaching approaches, the withdrawal of pupils for supplementary support remains the dominant approach. Teachers indicate that they would prefer a combination of withdrawal and in-class support as opposed to choosing one approach over the other. Teachers refer to the challenges posed by co-teaching in delivering instruction for pupils with SEN including planning time, teaching personalities and teaching styles in the multi-grade context. When co-teaching does occur, the most common form used is station teaching. The data demonstrate that teachers lack a clear understanding of the various in-class approaches available and what exactly they entail, and point to teachers' desire for continuing professional development (CPD) specific to co-teaching.