The relationship between two key factors of parental burnout of mothers of children with disabilities was studied on a population of 69 women. Exhaustion and helplessness--two subscales of the new instrument: Parental Burnout Measure-12--showed a decreasing correlation with coherence and personal resiliency. Multiple regression analysis showed coherence as more predicative of exhaustion, while personal resiliency of helplessness. The research did not present any relation between sociodemographic factors or the type of disability (Autism Spectrum Disorder versus Cerebral Palsy) and the level of parental burnout. The results can be considered as significant in designing actions that would support the activities of mothers in the rehabilitation of their children.