Mainstreaming and inclusion of students with special educational needs in regular education, challenge traditional concepts and common practices. Traditionally, special education has been a parallel yet separate educational system. Even though there is almost universal agreement on the goals of inclusion and mainstreaming, special education schools have proved to be resilient and still exist in many countries. One approach to promoting the goal of inclusion is the establishment of collaborative partnerships between special and mainstream schools. This paper will discuss models of such partnerships based on a literature review and visits to partner special and mainstream schools in Israel. Positive elements of these partnerships as well as challenges involved are presented.