ERIC Number: EJ1179155
Record Type: Journal
Publication Date: 2018-Jun
Abstractor: As Provided
Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia
Danzer, Enrico; Hoffman, Casey; D'Agostino, Jo Ann; Miller, Judith S.; Waqar, Lindsay N.; Gerdes, Marsha; Bernbaum, Judy C.; Rosenthal, Hannah; Rintoul, Natalie E.; Herkert, Lisa M.; Peranteau, William H.; Flake, Alan W.; Adzick, N. Scott; Hedrick, Holly L.
Journal of Autism and Developmental Disorders, v48 n6 p2112-2121 Jun 2018
To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.
Descriptors: Risk, Statistical Analysis, Incidence, Patients, Autism, Pervasive Developmental Disorders, Screening Tests, Comparative Analysis, Congenital Impairments, Diagnostic Tests, Developmental Delays, Neurology, Predictor Variables, Human Body, Multivariate Analysis
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
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