ERIC Number: EJ1179118
Record Type: Journal
Publication Date: 2018-Jun
Abstractor: As Provided
Autism Spectrum Symptomatology among Children with Duplication 7q11.23 Syndrome
Klein-Tasman, Bonita P.; Mervis, Carolyn B.
Journal of Autism and Developmental Disorders, v48 n6 p1982-1994 Jun 2018
Gold-standard diagnostic assessments of autism spectrum disorder (ASD) symptomatology were conducted on 63 children (mean CA: 8.81 years) with 7q11.23 duplication syndrome, one of the copy number variants identified by Sanders et al. ("Neuron" 70:863-885, 2011a) as associated with ASD. ASD classification rate was 39.6% for the Autism Diagnostic Interview-Revised and 25.4% for the Autism Diagnostic Observation Schedule-2 (ADOS-2). Based on these assessments combined with clinical judgment, 19.0% of children were diagnosed with ASD. Reasons for these discrepancies are discussed, as are differences in rate of diagnosis as a function of sex, age, and ADOS-2 module administered and differences in intellectual and adaptive behavior abilities as a function of presence or absence of ASD diagnosis and ADOS-2 module administered. Implications are addressed.
Descriptors: Autism, Pervasive Developmental Disorders, Clinical Diagnosis, Age Differences, Gender Differences, Diagnostic Tests, Observation, Children, Symptoms (Individual Disorders), Genetic Disorders
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Assessments and Surveys: Autism Diagnostic Observation Schedule
Grant or Contract Numbers: N/A