ERIC Number: EJ1178404
Record Type: Journal
Publication Date: 2018-May
Abstractor: As Provided
NO Is Required for Memory Formation and Expression of Memory, and for Minor Behavioral Changes during Training with Inedible Food in "Aplysia"
Briskin-Luchinsky, Valeria; Tam, Shlomit; Shabbat, Schlomit; Hurwitz, Itay; Susswein, Abraham J.
Learning & Memory, v25 n5 p206-215 May 2018
A learning experience may lead to changes in behavior during the experience, and also to memory expressed at a later time. Are signals causing changes in behavior during the learning experience related to the formation and expression of memory? We examined this question, using learning that food is inedible in "Aplysia." Treatment of an isolated buccal ganglia preparation with an NO donor elicited rejection-like motor programs. Rejection initiated by NO production is consistent with aspects of behavioral changes seen while animals learn, and with memory formation. Nonetheless, applying the NO donor during training had only minor effects on behavior during the training, and did not improve memory, indicating that the induction of rejection in the buccal ganglia is unlikely to be the means by which NO during training contributes to memory formation. Block of NO during memory retrieval prevented the expression of memory, as measured by a lack of savings in time to stop responding to food. Applying an NO donor to the cerebral ganglion while eliciting fictive feeding inhibited the expression of feeding activity, indicating that some NO effects on memory consolidation and on expression of memory may be via effects on the cerebral ganglion.
Descriptors: Memory, Behavior Change, Animals, Food, Rejection (Psychology), Brain, Training, Inhibition, Learning, Motor Reactions, Long Term Memory, Foreign Countries
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Location: Israel
Grant or Contract Numbers: N/A