The purpose of the present study was to identify the influencing factors of asynchronous e-learning system quality particular in developing countries via a review of current literature and a qualitative pre-study conducted at Jomo Kenyatta University of Agriculture and Technology (JKUAT). Despite the perceived benefits of these systems to overcome challenges facing education sector in the region, studies show that the majority of them have not been successful. After a thorough review of existing literature on developing countries and a qualitative pre-study conducted at JKUAT University, the study identified the factors that influence quality of e-learning systems as: Course Design, Content support, social support, and Student Characteristics, Instructor Characteristics, Technician Characteristics, Course Assessment and Institutional factors. It is hoped that the findings of this study will help those who are involved in the implementation of Learning Management System (LMS) assisted Asynchronous e-learning in developing countries prepare corrective measures and strategies based on these factors to avoid future system failures.