Clemson University Cooperative Extension Service has developed and is implementing a statewide population health management model aimed at leveraging key partnerships in South Carolina. The model delineates roles of key partners needed to operationalize statewide initiatives and drive the delivery of health extension in the state. Clemson University Cooperative Extension functions as the backbone organization within the model, achieving collective impact by using a collaborative approach for cultivating health as a shared value of entities throughout the state. Strong partnerships have been established, and rigorous evaluation is under way to determine the model's efficacy with regard to health indicators and population health outcomes.