Facilities are the foundation for safe and effective STEM teaching and learning, and the manner in which they are initially designed can either enhance or impede the quality of a program. This new focus on facilities in the U.S, and particularly in Texas, is needed to engage students in relevant and meaningful learning experiences that are aligned with post-secondary education and career standards. There are multiple layers of components that impact the efficacy of a safe and effective STEM Education program. Program needs, space, and design are critical features described here. This article also highlights various STEM facilities throughout the state of Texas.