The US medical schools are characterized by a significant progress in the usage of information and communication technologies for professional purposes and communication skills development. This advance was influenced by a sequence of social, academic, technological and financial conditions, namely: permanent research in the branch of modernization of higher medical education; application of a student-centered approach in education and patient-centered approach in clinical practice; physician-patient interaction skills development and their evaluation during clerkships; implementation of the subjects aimed at communication training into the undergraduate curricula; technological progress and implementation of ICTs in undergraduate clinical and communication training of future doctors. A profound analysis of the state of ICT implementation for professional communication skills development in Ukraine and the USA has showed hardly any common features. Thus, the process of ICTs application is advanced in medical schools of the USA and still challenging in Ukraine. In the USA communication training involves mainly virtual patients and in our country this training is more theoretical and applies university web-sites, on-line learning courses and social media learning sources. Material and technical as well as complicated political and economic conditions of higher medical institutions in Ukraine are established as the most significant factors that influence domination of the US universities over ours. The article states that determined progressive ideas of American experience in the scope of ICTs application for medical communication skills development should be considered in order to improve and modernize this process in our country.