Attention toward social entrepreneurship has increased worldwide, particularly within younger generations. Based on the identified model of social entrepreneurial intentions, this study proposed a multiple mediation framework to examine the mediating role of entrepreneurial creativity for university students. It also compared the differences between Taiwanese (N = 311) and Hong Kong students (N = 311). Through a survey using both online and offline channels, the results of Study 1 confirmed the factor structures of the 3 scales, involving 5 antecedents of social entrepreneurial intention (i.e., empathy, moral obligation, self-efficacy, perceived social support, and prior experience with social problems), 2 factors of entrepreneurial creativity (i.e., originality and usefulness), and 2 factors of social entrepreneurial intention (i.e. conviction and preparation). The results of Study 2 supported the proposed multiple mediation model across regions. Prior experience with social problems, perceived social support, and originality were identified as the 3 most influential factors affecting the social entrepreneurial intentions of university students. The major differences between Taiwan and Hong Kong involved prior experience, empathy, self-efficacy, perceived social support, and usefulness.