Learning and retaining science content may be increased by applying the basic science material to real-world situations. Discussing cases with students during lectures and having them participate in laboratory exercises where they apply the science content to practical situations increases students' interest and enthusiasm. A summer course in veterinary anatomy and physiology for high school students was developed by staff at the Cornell University College of Veterinary Medicine to provide an opportunity to relate anatomy and physiology content to topics in veterinary medicine. The course reflects this concept of relating science content to real-world situations. Students were enthusiastic about the course material and presentation, and were appreciative of the applications to relevant situations such as clinical veterinary medicine.