NotesFAQContact Us
Search Tips
Peer reviewed Peer reviewed
Direct linkDirect link
ERIC Number: EJ1173160
Record Type: Journal
Publication Date: 2018-Mar
Pages: 5
Abstractor: As Provided
ISSN: ISSN-0021-9584
Undergraduate Organic Experiment: Tetrazole Formation by Microwave Heated (3 + 2) Cycloaddition in Aqueous Solution
DeFrancesco, Heather; Dudley, Joshua; Coca, Adiel
Journal of Chemical Education, v95 n3 p433-437 Mar 2018
An undergraduate experiment for the organic laboratory is described that utilizes microwave heating to prepare 5- substituted 1H-tetrazole derivatives through a (3 + 2) cycloaddition between aryl nitriles and sodium azide. The reaction mixture is analyzed by thin layer chromatography. The products are purified through an acid-base extraction and recrystallization. Characterization is accomplished using melting point, infrared, 1 H NMR, and [superscript 13]C NMR spectroscopy. Students are tasked with determining and confirming the structure of their product based on their assigned nitrile and characterization data
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A