In this article we discuss interdisciplinary teaching and research in Latin America through the lens of Mexican perspectives, in particular the experiences at the National Autonomous University of Mexico (UNAM). The history of these experiences goes back to the creation of the frst interdisciplinary education programs in Mexico in the 1970s and the foundation of the Center for Interdisciplinary Research in the Sciences and Humanities in 1986 at the UNAM. With this Center's contributions as the framework, we examine objectives and instruments of academic policy in our country in order to understand how methods of evaluation work. We study not only the ways of academic interdisciplinarity but also the main theoretical and epistemological focuses in university environments. From this analysis of Mexican experience, we obtain important information that can be useful in the process of integrating knowledge amongst other countries of Latin America.