The purpose of this study is to investigate the relationship between career adaptability and self-esteem, and analyze the moderating role of social support in this relationship on a sample of 313 young adults. The results of the study confirm that career adaptability is significantly predicted by self-esteem. Moreover, findings suggest that (1) self-esteem enhances career adaptability, (2) perceived social support positively predicts career adaptability, and (3) perceived social support plays a moderating role in the relationship between perceptions of self-esteem and career adaptability sub-scales. Self-esteem and social support positively predict young adults' career adaptability above and beyond the effects of demographics.