When compared to their non-gifted peers, gifted students who have high-level talent, motivation and creativity are significantly different from other students in many respects. In addition to their distinct mental, physical and educational features, developed sense of humor is another distinct feature of these students. Also, currently no literature has been published regarding the effect of being giftedness on cartoon drawing. So, the purpose of this study was to compare the ability of gifted and non-gifted students in cartoon-drawing practices and reflection of humor in their drawings. This paper reports the results of a study conducted through survey method and case study as one of the qualitative research method. 59 gifted and non-gifted students participated in the study. Participants were selected through deviant case sampling and convenient sampling. Data was collected through cartoons and analyzed through document analysis. In order to gather data, participants were asked to draw a cartoon related to a certain situation and jokes. Three experts, according to the assessment scale, evaluated cartoons drawn by both groups, and students' cartoon scores, drawing and humor scores were compared by analysis of the evaluation results. Data showed that skills of creating, drawing and reflecting humor to the cartoons of gifted students were at medium level, and those of non-gifted students were insufficient. Gifted students were successful at the same level in creating cartoons based on a situation and a funny, and in drawing and reflecting humor to cartoons. Also, it was seen that non-gifted students were more successful at creating cartoons based on a funny than a situation.