This study discusses the influence of classroom activities in the mainstream schools and special schools in Bulgaria. The study presents classroom activities related to the school subject Human and Nature. This school subject is part of the curriculum both at special and at mainstream schools. There are detailed explanations and descriptions as well as concrete methodological directions for each classroom activity. Some photographs are included in the text in order to achieve better visualization of the classroom activities described. The developed classroom activities in Natural Sciences for students with special needs, are just a small step in the understanding of the idea that all learners, regardless of their impairments, can participate in the learning process. This is in accord with the initiative of most nations to place more emphasis on the education of people with special needs, supporting their explorative aspirations and desire to know the surrounding world.