Individuals with print disabilities have difficulty processing information through visual means and rely heavily on spoken input. Mathematics and fields that have a heavy emphasis on mathematics are difficult for these individuals because of ambiguity inherent in typical everyday spoken renderings of mathematical expressions. MathSpeak is a set of rules for speaking mathematical expressions in a non-ambiguous manner. The present study tested the efficacy of MathSpeak rules for disambiguation of auditory renderings of spoken mathematics. Findings suggest that MathSpeak is efficacious for disambiguating spoken mathematics.