The Common Core State Standards (CCSS); the Next Generation Science Standards (NGSS); and the College, Career, and Civic Life (C3) Framework for Social State Standards are bringing many changes to schools and classrooms across the United States. This article suggests using the power of questions to make connections across seemingly disparate disciplinary goals to help bring greater balance, coherence and meaning to the academic lives of teachers, students, and parents. The paper begins with a rationale for using guiding questions within the context of PDS and then includes an example, tools and suggestions for professional development with PDS stakeholders.