ERIC Number: EJ1169067
Record Type: Journal
Publication Date: 2018-Feb
Abstractor: As Provided
Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder
Rausch, Annika; Zhang, Wei; Beckmann, Christian F.; Buitelaar, Jan K.; Groen, Wouter B.; Haak, Koen V.
Journal of Autism and Developmental Disorders, v48 n2 p572-582 Feb 2018
Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F[subscript 1] = 7.842, p = 0.008) and its volume correlated significantly with symptom severity (social skills: r = 0.548, p = 0.009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway.
Descriptors: Brain Hemisphere Functions, Interpersonal Competence, Autism, Pervasive Developmental Disorders, Intervention, Therapy, Comparative Analysis, Symptoms (Individual Disorders), Severity (of Disability), Prediction, Adolescents
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
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