This study investigated how orientation programs predict student retention in distance learning at the University of Cape Coast. A correlational research design was employed for the study. The target population was level-200 students in the distance education program at the university. Seven hundred and twenty-seven participants were selected from a sampling frame of 8,731. Responses of 625 out of the 727 questionnaires administered were used for analysis. The hypothesis for the study was set at p < 0.05. The findings of the study revealed that the orientation program is a significant predictor of student retention at p < 0.001.