Majority of learners in our classrooms are digital natives or Millennials--a category of learners who tend toward independence and autonomy in their learning styles. The primary challenges then facing instructors include: How do digital natives learn and how do you teach them? The answers to these questions will help instructors to: (a) identify and develop learning instructional offerings that are appropriate to their cognitive learning patterns, and (b) find strategies that focus on millennials' interest and use of technology. This article highlights the need to integrate active student-centered strategies into classroom instruction to support digital natives to learn effectively with technology.