This paper advocates for the use of Information and Communication Technologies (ICTs) and indigenous languages for the actualization of Millennium Development Goals (MDGs) in Nigeria because both tools are capable of transforming the rural and urban populace. It explores the MDGs so as to unravel the ways ICTs and indigenous languages can facilitate the speedy actualization of MDGs in Nigeria, a country with peculiar cultural heritage and with over 750 indigenous languages. It also analyzes some of the contending constraints confronting Nigeria from actualizing MDGs such as corruption, extreme poverty, lack of attention to indigenous languages, high cost of ICTs which are products of bad leadership. The effective use of Nigeria's different indigenous languages and ICTs, it maintains, remains the most effective way towards educating Nigerians and achieving the MDGs in Nigeria come 2015.