This study was carried out to ascertain the influence of social networking sites activities (twitter and Facebook) on secondary school students' interest in learning It also considered the impact of these social networking sites activities on location of the students. Two research questions and two null hypotheses guided the study. Mean and Standard Deviation were used to answer the research questions, while t-test statistics was applied in testing the null hypotheses. In carrying out the study, the researchers adopted Ex-post Facto research design. The sample of the study consisted of 240 senior secondary school Two (SSS11) students from public schools. Multi-stage sampling technique was used to select 120 students from the urban and 120 students from the rural areas. A 15-item Questionnaire was used in data collection. Cronbach Alpha was used to establish the internal consistency of the instruments. Cronbach Alpha Coefficients values of 0.88 and 0.72 were obtained. The findings of the study indicated that there is a significant influence of students' Twitter and Facebook activities over their interest in learning. Students in urban schools had higher Mean Score interest in learning than those in rural location. The result also indicated that there is no significant difference in the Mean interest ratings of urban and rural students.