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ERIC Number: EJ1166944
Record Type: Journal
Publication Date: 2018-Jan
Pages: 6
Abstractor: As Provided
ISSN: ISSN-0021-9584
Asymmetric Aldol Additions: A Guided-Inquiry Laboratory Activity on Catalysis
King, Jorge H. Torres; Wang, Hong; Yezierski, Ellen J.
Journal of Chemical Education, v95 n1 p158-163 Jan 2018
Despite the importance of asymmetric catalysis in both the pharmaceutical and commodity chemicals industries, asymmetric catalysis is under-represented in undergraduate chemistry laboratory curricula. A novel guided-inquiry experiment based on the asymmetric aldol addition was developed. Students conduct lab work to compare the effectiveness of different catalysts in catalyzing the asymmetric aldol addition of a ketone and an aldehyde. Working in pairs, students use a variety of analytical techniques including 1-D and 2-D NMR spectroscopy and chiral chromatography and write their final report in the format of an ACS style publication. Although this experiment was designed for an advanced undergraduate synthesis laboratory course, it can be readily adapted for use in an organic or an inorganic laboratory course.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: Teachers
Language: English
Sponsor: National Science Foundation (NSF)
Authoring Institution: N/A
Grant or Contract Numbers: CHE1056420