This article reports on a teaching intervention for year 9 or 10 students (age 13-15) in secondary school biology and religious education (RE) lessons that was partly intended to deepen students' reflections, empathy and literacy when considering the similarities, differences and relationships between religion and science. The intervention proved to be generally successful in meeting its aims for the students and also led to a number of the participating teachers changing their views in ways that were more positive about the worth of examining such issues in the classroom.