This article discusses the challenges and consequences of family separation and reunification during immigration from Latin America to the U.S. The historical pattern of paternal immigration as well as the recent rise in maternal immigration are discussed. The article addresses the impact of length of separation and how separation impacts family dynamics and school success. Recommendations are given for how schools can address the challenges that students face related to family separation and reunification during immigration including creating and fostering school-based mental health services, teacher training, school-caregiver and school-family partnerships, teacher-student relationships and peer relationships, and other supports.