Environmental pollution occurring in industrial districts represents a serious issue not only for local communities but also for those industrial productions that draw from the territory the source of their competitiveness. Due to its ability to take into account the needs of different stakeholders, the collective impact approach has the potential to address these problems, whereas single actors may not have the resources. The implications of the paper are addressed to institutions for industrial policies which individuate potential courses of action for developing and strengthening clustering-based approaches, as well as implementing viable policies in support of the sustainable competitive model.