The Aspen Institute's National Commission on Social, Emotional, and Academic Development united a broad alliance of leaders to speak with a unified voice about the urgency of integrating social and emotional development into the fabric of K-12 education. The commission convened a group of scientists, researchers, and academics across disparate fields to develop consensus statements on what research says about integrating social, emotional, and academic development. Schools and other organizations that work with children must promote development across multiple areas and address the skills and beliefs of educators and other adults in schools; organizational culture, climate, and norms; and routines and structures that guide basic interactions and instruction. As described in this article, such approaches are most effective when designed to match the needs and opportunities of specific contexts, organizations, and communities.