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ERIC Number: EJ1164233
Record Type: Journal
Publication Date: 2018-Jan
Pages: 5
Abstractor: As Provided
ISSN: ISSN-1072-0502
Sex Differences in Fear Discrimination Do Not Manifest as Differences in Conditioned Inhibition
Foilb, Allison R.; Bals, Julia; Sarlitto, Mary C.; Christianson, John P.
Learning & Memory, v25 n1 p49-53 Jan 2018
Distinguishing safety from danger is necessary for survival, but is aberrant in individuals with post-traumatic stress disorder (PTSD). While PTSD is more prevalent in women than men, research on sex differences in safety learning is limited. Here, female rats demonstrated greater fear discrimination than males in a CS+/CS- paradigm. To determine if this sex difference transferred to fear inhibition, rats were tested for conditioned inhibition in a summation test with the CS+ and CS- presented in compound; no sex difference emerged. The results suggest sex differences in the neural mechanisms of discrimination learning but not recall of a fear inhibitor.
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A