With the developments in information and communication technologies, books which are fundamental information sources for students throughout their education and training process are being transformed into electronic book (e-book) formats. E-books provide interactive environments, and they are also updateable materials, which shows that, in time, they can almost completely replace printed materials. In addition, there are no spatial and temporal limitations in conveying the lesson content to students using e-books, and they are accessible online as well, both of which increase the preference toward e-books. In this context, the study aimed to examine the e-book design process based on the ADDIE model used by the pre-service teachers in the Computer and Instructional Technologies department. E-books were include subjects radioactivity, acid rain and the greenhouse effect. The study was conducted throughout a period of 12 weeks with 54 sophomores in the Computer and Instructional Technologies department of Giresun University's Education Faculty who were taking the Material Design and Use in Education course during the 2015 Fall semester. The study data were collected using data collection forms and reflection reports. The data derived from these tools were analyzed using content analysis. The study results revealed that the pre-service teachers had problems particularly in the development process of the e-books. In addition, the pre-service teachers recognized their deficiencies when designing their e-books, and they eliminated these deficiencies to a great extent.