Research Findings: Temperament, often defined in terms of reactive and regulatory tendencies, has been shown to predict child outcomes over and above other risk factors and represents a critical aspect of social-emotional development. The present article is a systematic review of temperament-based interventions targeting caregivers, wherein the aim is to inform caregivers about temperament in an effort to influence a variety of outcomes, such as goodness of fit, parenting stress, achievement, and behavior problems. In total, 13 randomized and nonrandomized trials were reviewed, with promising outcomes. Temperament-driven interventions have demonstrated the capacity to increase parental knowledge of temperament, reduce behavior problems, improve math and reading achievement, create more positive teacher-child relationships, and reduce numbers of medical visits. Caregivers report satisfaction with and usefulness of the interventions, which suggests promise for future application of temperament-based approaches. Temperament-driven interventions can be leveraged to improve multiple developmental outcomes, especially in early childhood, and are useful for both teachers and parents. Practice or Policy: Implications of temperament-based interventions for early childhood educators are discussed, as are limitations and future directions.