ERIC Number: EJ1162914
Record Type: Journal
Publication Date: 2017-Dec
Abstractor: As Provided
Familiarity with a Vocal Category Biases the Compartmental Expression of "Arc/Arg3.1" in Core Auditory Cortex
Ivanova, Tamara N.; Gross, Christina; Mappus, Rudolph C.; Kwon, Yong Jun; Bassell, Gary J.; Liu, Robert C.
Learning & Memory, v24 n12 p612-621 Dec 2017
Learning to recognize a stimulus category requires experience with its many natural variations. However, the mechanisms that allow a category's sensorineural representation to be updated after experiencing new exemplars are not well understood, particularly at the molecular level. Here we investigate how a natural vocal category induces expression in the auditory system of a key synaptic plasticity effector immediate early gene, "Arc/Arg3.1," which is required for memory consolidation. We use the ultrasonic communication system between mouse pups and adult females to study whether prior familiarity with pup vocalizations alters how Arc is engaged in the core auditory cortex after playback of novel exemplars from the pup vocal category. A computerized, 3D surface-assisted cellular compartmental analysis, validated against manual cell counts, demonstrates significant changes in the recruitment of neurons expressing Arc in pup-experienced animals (mothers and virgin females "cocaring" for pups) compared with pup-inexperienced animals (pup-naïve virgins), especially when listening to more familiar, natural calls compared to less familiar but similarly recognized tonal model calls. Our data support the hypothesis that the kinetics of Arc induction to refine cortical representations of sensory categories is sensitive to the familiarity of the sensory experience.
Descriptors: Brain Hemisphere Functions, Animals, Auditory Stimuli, Genetics, Memory, Interpersonal Communication, Familiarity, Auditory Perception, Mothers
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: firstname.lastname@example.org; Web site: http://learnmem.cshlp.org
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD); National Institutes of Health (DHHS); National Institute of Neurological Disorders and Stroke (NIH)
Authoring Institution: N/A
Identifiers - Location: Georgia (Atlanta)
Grant or Contract Numbers: R01DC008343; 5R90DA033462; P30NS055077