The relevance of the study is due to the need to overcome social exclusion of adolescents and young people caused by their health condition and restrictions on life in the context of inclusion trends in the worldwide social policy and practice. In this connection, the article aims to justify and search for hospitalsubstitute format of social and pedagogical support for young people with psychophysical behavior disorders of an autism spectrum disorder (ASD) type. The leading approach in the research of this issue is an integrative activity-based approach that allows comprehensive consideration of socio-political, organizational-pedagogical and technological opportunities for active inclusion of families with children and adolescents with ASD into joint activities in a social settlement. In the article, results of sociological, and psychological-pedagogical studies of the issue of social inclusion of individuals at risks of their exclusion from society are presented; various types of social integration practices are typologically disclosed; the author's structural-functional model of a supported living arrangement is substantiated; conditions and possibilities for its implementation by a public organization of parents having children with autism in the regional context as exemplified by a rural settlement are identified and shown. The information presented in the article is of practical value for specialists in social pedagogy and work, as well as for those who are trained for concrete competences of social support of families having children with disabilities. The results of the given socio-pedagogical project may be useful for the development of the social movement of parents.