A sample of 720 college students from 10 different universities at the Guangzhou Higher Education Mega Center are investigated using the Social Support Scale, the Prosocial Behavior Scale, and the Interpersonal Trust Scale. Data are analyzed using SPSS20.0 and Amos7.0. Results show that the subjective support and support utilization of college students directly influences prosocial behavior, and indirectly affects prosocial behavior through the influence of emotional trust and quality trust. Additionally, interpersonal trust plays an intermediary role in the influence of social support on pro-social behavior.