Recently researchers have begun exploring the efficacy of interventions designed to improve text comprehension skills for students with developmental disabilities (DD). Text comprehension is essential for understanding academic content as students with disabilities make progress in the general education curriculum. This article focuses on single case design (SCD) studies of interventions and supports for improving text comprehension skills for students with DD. Specifically, the article examines elements essential for rigorous single case design research in this area. After reviewing the research, we provide recommendations for improving rigor of research in this area.