This article discusses the use of ePortfolios in interdisciplinary online adult degree programs at two universities. Whereas one university uses the ePortfolio only in a capstone course, the other institution introduces the ePortfolio in an introductory course that focuses on goal setting and then has students add content to the ePortfolio in the final course of their program of study. Additionally, one institution implemented the ePortfolio for assessment purposes, while the other did not. The study of these cases explores the different approaches to ePortfolio use in two interdisciplinary adult degree programs, as well as the benefits of ePortfolio use within this student population.