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ERIC Number: EJ1159464
Record Type: Journal
Publication Date: 2017-Oct
Pages: 5
Abstractor: As Provided
ISSN: ISSN-0021-9584
Chemical Upcycling of Expired Drugs: Synthesis of Guaifenesin Acetonide
Barcena, Homar; Maziarz, Katarzyna
Journal of Chemical Education, v94 n10 p1538-1542 Oct 2017
In an effort to repurpose expired guaifenesin tablets, experiments devised for practical instruction are reported for the preparation and isolation of the guaifenesin acetonide using a microscale kit. The laboratory experiment successfully utilizes a waste chemical in lieu of a fine chemical to illustrate the principles behind protecting groups in organic synthesis. Oxidative cleavage is used to demonstrate the stability of the acetonide protecting group. Lastly, methanolysis of the acetal demonstrates the reversibility of the functional group transformation.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A