American Indians, Alaska Natives, and Native Hawaiians (AI/AN/NH) experience the lowest rates of college retention and significant barriers to graduation. In addition, AI/AN/NH individuals face health challenges that include higher rates of obesity, overweight, and type 2 diabetes. We designed a culturally relevant life skills curriculum based on family and consumer science standards to promote educational achievement, self-efficacy, and healthful food choices among tribal college students. The Life Skills at a Tribal College course was delivered by tribal college Extension professionals in a family meal-style environment and involved culturally appropriate, traditional ways of learning to promote positive educational and health outcomes.