This article argues that the stance toward global regulatory initiatives is influenced by the extent to which these regulatory initiatives threaten the comparative institutional advantages of the national economy. The cases through which this proposition is examined are the showpieces of Germany and Ontario: their system of vocational education and training. The article draws on the Varieties of Capitalism literature to explore the factors that implicated the most into the educational reforms introduced in Germany in the context of the Bologna Process. In the case of Ontario, the paper used educational reforms in the context of two OECD reports, Learning for Job and A Skills beyond School. The paper concludes that comparative institutional advantage and the institutional complementarity sustaining it explain the different trajectories countries take in their response to global pressures.