Purpose: Tobacco use is a major public health issue in developing countries, with substantial initial exposure in childhood. School-based educational resources promise to reduce tobacco initiation and experimentation among children from low-income countries. Research in this area is scant. The study goal was to test the impact of an evidence-based US educational resource on tobacco-use health risk knowledge among Tanzanian children. Methods: "Eglin Long-Horn of Nightshade County" is a potentially transferable children's storybook/curriculum focused on reducing tobacco-use intent. A pre-/post-survey assessed the impact of "Eglin" on knowledge of tobacco exposure health risks among secondary school-age residents of a Tanzanian children's home. Results: Of the 52 participants, 35 returned both surveys. School grade ranged from Forms 1 to 4, with 51% in Forms 1-2 (ages 14-15). There was an overall increase from 60% to 93% (p < 0.0001) in correct survey responses, with an increase seen in all grade levels. Conclusion: A US-based tobacco awareness storybook/curriculum improved Tanzanian children's knowledge of tobacco-use health risks.