This piece of article is culled from a larger study. The study investigated the relationship between family-work conflict, Type-E personality and stress in married female Nigerian University Administrators. The study adopted ex-post facto design. The sample consisted of 800 female administrators in the senior cadre of executive/administrative officers and above drawn from five Nigerian universities. Two self-constructed instruments on family-work conflict and stress was used to elicit information from the participants which was tagged "Nigerian University Married Female Administrators Stress Scale" (NUMFASS) on one side and Type-E personality on the other hand. The validity and reliability of the instruments was ascertained using Cronbach Alpha Coefficient with a result of 0.73 having applied it on a sample size of 30 respondents as pilot study. Pearson Product Moment Correlation and multiple regression analyses were used to analyze the data generated from the hypotheses that were generated for the study. The findings of the study revealed that family-work conflict and type-E personality significantly induce stress in married female Nigerian University Administrators. The implication is that psycho-social, domestic and working place work load variables have high potency for causing stress in married female Nigerian University Administrators and so should be taken into consideration anytime stress is to be managed or treated. Two types of psychological coping strategies: problem focused and emotion focused strategies were recommended in treating stress among the married female administrators.