This study aims to determine the relationship between the self-efficacy perceptions of the prospective teachers and the levels of their professional competence. In the study, relational screening model is used and it is investigated whether prospective teachers' perceptions of academic self-efficacy and professional competence differed according to various variables. The population of the research constitutes 1430 university students (prospective teachers) who are educated in Inonu University Pedagogical Formation Education (PFE) Program in 2015-2016 academic year. In the sample of the study, there are 537 participants who were determined by random sampling method. The Ohio Teacher Competence Scale and The Academic Self-Efficacy Scale (Turkish versions) are used as a data collection tool. In the analysis of the data, the standard deviation, frequency, percentage and arithmetic mean of respondents were calculated. One-way analysis of variance, ANOVA and Scheffe Test are used. The main result of this research is that the perceptions of academic self-efficacy of prospective teachers are "Moderate" but their perceptions of professional competence are in level "Very". According to this result, prospective teachers are of the opinion that the teaching profession can be achieved with "a moderate level of academic competence".