The study investigated the constraints facing the teaching of entrepreneurship education in colleges of education in South South Nigeria. A research question was raised and three hypotheses were formulated for the study. A descriptive survey design was used for the study. The population which also served as sample comprised 206 Business Education lecturers. The researcher used a questionnaire which has 24 items. The content and face of the instrument was validated by experts in business education and measurement and evaluation. The questionnaire has a reliability value of 0.92 using Cronbach alpha. Mean score and standard deviation were used to answer the research question while t-test was used to test the hypothesis at 0.05 level of significance. The findings are ineffective monitoring, ineffective evaluation, insufficient time, poor welfare package and inadequate teaching facilities are some of the constraints facing the teaching of entrepreneurship education in colleges of education. It was, therefore, recommended that adequate teaching facilities should be provided by the school authorities to enhance quality teaching of entrepreneurship education. Adequate teachers should also be employed by school authorities.