Measuring attitudes and opinions employing agree/disagree (A/D) questions is a common method in social research because it appears to be possible to measure different constructs with identical response scales. However, theoretical considerations suggest that A/D questions require a considerable cognitive processing. Item-specific (IS) questions, in contrast, offer content-related response categories, implying less cognitive processing. To investigate the respective cognitive effort and response quality associated with A/D and IS questions, we conducted a web-based experiment with 1,005 students. Cognitive effort was assessed by response times and answer changes. Response quality, in contrast, was assessed by different indicators such as dropouts. According to our results, single IS questions require higher cognitive effort than single A/D questions in terms of response times. Moreover, our findings show substantial differences in processing single and grid questions.