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ERIC Number: EJ1157938
Record Type: Journal
Publication Date: 2017-Nov
Pages: 9
Abstractor: As Provided
ISSN: ISSN-1072-0502
The L-Type Voltage-Gated Calcium Channel Ca [subscript V] 1.2 Mediates Fear Extinction and Modulates Synaptic Tone in the Lateral Amygdala
Temme, Stephanie J.; Murphy, Geoffrey G.
Learning & Memory, v24 n11 p580-588 Nov 2017
L-type voltage-gated calcium channels (LVGCCs) have been implicated in both the formation and the reduction of fear through Pavlovian fear conditioning and extinction. Despite the implication of LVGCCs in fear learning and extinction, studies of the individual LVGCC subtypes, Ca[subscript V]1.2 and Ca[subscript V] 1.3, using transgenic mice have failed to find a role of either subtype in fear extinction. This discontinuity between the pharmacological studies of LVGCCs and the studies investigating individual subtype contributions could be due to the limited neuronal deletion pattern of the Ca[subscript V]1.2 conditional knockout mice previously studied to excitatory neurons in the forebrain. To investigate the effects of deletion of Ca[subscript V]1.2 in all neuronal populations, we generated Ca [subscript V]1.2 conditional knockout mice using the synapsin1 promoter to drive Cre recombinase expression. Pan-neuronal deletion of Ca[subscript V]1.2 did not alter basal anxiety or fear learning. However, pan-neuronal deletion of Ca[subscript V]1.2 resulted in a significant deficit in extinction of contextual fear, implicating LVGCCs, specifically Ca[subscript V]1.2, in extinction learning. Further exploration on the effects of deletion of Ca[subscript V]1.2 on inhibitory and excitatory input onto the principle neurons of the lateral amygdala revealed a significant shift in inhibitory/excitatory balance. Together these data illustrate an important role of Ca[subscript V]1.2 in fear extinction and the synaptic regulation of activity within the amygdala.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A