The primary purpose of schools and colleges of pharmacy is to produce pharmacists capable of providing competent patient centered care. To accomplish this goal, pharmacy students must learn and retain a great deal of knowledge as well as develop professional attitudes and behaviors. In recent years, several articles have been published questioning the professionalism of pharmacy students and whether colleges of pharmacy are promoting professionalism (Hammer, 2003; Chisholm, 2004). Professionalism has a broad definition and encompasses every aspect of the duty of a pharmacist. The definition of professionalism and a discussion of professional socialization roadblocks are important considerations when establishing guidance to students and faculty. Responsibilities of the student and responsibilities of the educator should be clear to all involved. E-professionalism presents a new consideration when outlining professionalism standards to pharmacy students and should be addressed as well. Colleges of pharmacy must develop methodologies to aid in the development of professionalism among pharmacy students in all types of learning environments, whether a student attends a traditional campus or a distance campus. Finally, with the implementation of distance campuses, professionalism is presented with new and unique challenges which require continuous evaluation to prevent negative outcomes.