The goal of this study was to research the frequency of the use of diverse types of humor in the college classroom for a possible association with student interest in course material. This relationship was studied using quantitative methods. Participants answered questions about their interest in course material and the type of humor that their instructor used in the classroom. The study involved 195 undergraduate students ranging in age from 18 to 25. A factor analysis recognized two separate types of humor (relevant/appropriate and non-relevant). The study found that both relevant/appropriate humor and non-relevant humor predicted student interest. The more relevant/appropriate humor used the more student had interest in course materials. As well, the more non-relevant humor used the less students reported interest in course materials. No differences were found between the gender of students in the classroom when examining this question of humor and interest.